Positive natural selection in the human lineage pdf

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A subscription may be required. Sabeti PC ,. Schaffner SF ,. Fry B Search articles by 'Fry B'. Fry B ,. Lohmueller J Search articles by 'Lohmueller J'. Lohmueller J ,. Varilly P ,. Shamovsky O Search articles by 'Shamovsky O'. Shamovsky O ,. Palma A Search articles by 'Palma A'. Palma A ,. Mikkelsen TS ,. Altshuler D Search articles by 'Altshuler D'. Altshuler D ,. Lander ES. Affiliations All authors 1. Share this article Share with email Share with twitter Share with linkedin Share with facebook.

Abstract Positive natural selection is the force that drives the increase in prevalence of advantageous traits, and it has played a central role in our development as a species. Until recently, the study of natural selection in humans has largely been restricted to comparing individual candidate genes to theoretical expectations.

The advent of genome-wide sequence and polymorphism data brings fundamental new tools to the study of natural selection. It is now possible to identify new candidates for selection and to reevaluate previous claims by comparison with empirical distributions of DNA sequence variation across the human genome and among populations. The flood of data and analytical methods, however, raises many new challenges.

Here, we review approaches to detect positive natural selection, describe results from recent analyses of genome-wide data, and discuss the prospects and challenges ahead as we expand our understanding of the role of natural selection in shaping the human genome.

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A new approach for using genome scans to detect recent positive selection in the human genome. Using genome scans of DNA polymorphism to infer adaptive population divergence. Joining Europe PMC. Tools Tools overview. ORCID article claiming. Journal list. Grant finder. Some features of the site may not work correctly. DOI: Sabeti and Stephen F. Schaffner and B. Shamovsky and A.

Sabeti , S. Lander Published 16 June Medicine, Biology Science Positive natural selection is the force that drives the increase in prevalence of advantageous traits, and it has played a central role in our development as a species. Until recently, the study of natural selection in humans has largely been restricted to comparing individual candidate genes to theoretical expectations. The advent of genome-wide sequence and polymorphism data brings fundamental new tools to the study of natural selection.

It is now possible to identify new candidates for… Expand. View on AAAS. Save to Library Save. Create Alert Alert. Share This Paper. Background Citations. Methods Citations. Results Citations. Topics from this paper. Natural Selection. Variation Genetics. Citation Type. Has PDF. Publication Type. More Filters.

Positive selection in the human genome: from genome scans to biological significance. Annual review of genomics and human genetics. Selection and adaptation in the human genome.

View 2 excerpts, cites methods. The molecular signature of selection underlying human adaptations. American journal of physical anthropology. Highly Influenced.